AI-Supported Science Research Workflow (Biology Example)
🔬 AI-Supported Science Research Workflow (Biology Example)
Goal: Help students use AI productively when developing research papers or other science-based assignments.
This workflow is designed to support student use of AI in science-based research assignments and can be adapted across biology topics and course levels. (This workflow is adapted from the AI-Integrated Research (Archaeological Dig) model and demonstrates how AI tools can support scientific research processes.)
Step 1: Explore a Topic and Refine a Research Direction
You can begin with a topic, question, or area of interest. There are two useful ways to begin discovery in science research:
Option A: Literature- and citation-based discovery
Use Semantic Scholar to begin from the scholarly literature itself.
- Identify important papers, authors, and terminology
- See how a topic is described in the research literature
- Build vocabulary for database searching
Option B: Research-question-based discovery
Use Consensus to begin from a topic, prompt, or rough question and refine it into a researchable direction.
- Brainstorm focused, researchable questions
- Identify technical vocabulary and synonyms
- Generate concepts and phrases to try in databases
Try this (Consensus prompt):
I am a biology student preparing a research paper. I am interested in:
[insert topic]
Suggest several focused researchable questions that:
- Investigate a specific biological mechanism or process
- Are supported by peer-reviewed research
- Could be explored using experimental evidence
- could appeal to high school, undergraduate or graduate students
- Include a contentious question for each
For each question, include keywords and search phrases for databases like PubMed or Web of Science.
Important: Both approaches are starting points. Strong research still moves into database searching and close reading of primary research.
Step 2: Search Strategically Across Databases
Regardless of how students begin, strong research moves into structured database searching.
No single database indexes all scientific literature. Choose databases based on the research angle and compare results.
🔬 Major Research Databases
- PubMed — strong for biomedical and molecular biology topics
- Web of Science — interdisciplinary; excellent for citation tracking
- Science Citation Index — citation network exploration
- Biological Abstracts — broad life sciences coverage
- Wildlife & Ecology Studies Worldwide — useful for ecological or environmental topics
📘 Discipline-Specific Journal Platforms
- American Chemical Society (ACS) Journals — useful for biochemical or small molecule research
- Nature Online — high-impact; helpful for identifying major studies
- Public Library of Science – Biology — open access research
- Science Magazine Online — high-impact interdisciplinary research
Best Practice:
- Search at least two databases.
- Compare terminology and results across platforms.
- Use citation chaining (“Cited by” and reference lists).
- Refine your Boolean search string as vocabulary evolves.
Your goal is to locate peer-reviewed primary research articles with experimental data, not summaries or background overviews.
Not sure which database best fits the assignment or topic? Consider the research angle below.
🔎 Advanced Strategy
If a topic spans multiple biological scales (for example, gene regulation + metabolism + ecological impact), students may need to search different databases separately.
- Molecular mechanisms → PubMed
- Interdisciplinary or citation mapping → Web of Science
- Ecological systems → Wildlife & Ecology Studies Worldwide
- Metabolites or signaling molecules → ACS Journals
Strong science research often requires strategic comparison across databases.
Step 3: Evaluate Experimental Strength
Before using an article, students should confirm that it:
✔ Contains a Methods section
✔ Includes original experimental data (figures/tables)
✔ Tests a hypothesis or research question
✔ Uses appropriate controls
Review articles are useful for background, but they should not be the main evidence for most research assignments.
Reference Management
Zotero: Save citations, attach PDFs, organize sources, and generate bibliographies.